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It is not known whether adiponectin is inversely associated with insulin resistance and systemic inflammation. Associations of adiponectin with insulin sensitivity and inflammatory markers were studied in 191 elderly, nondiabetic Chinese subjects. Serum adiponectin was lower in sedentary subjects than in active subjects (16.5 +/- 5.3 microg/mL vs. 23.8 +/- 9.1 microg/mL; P < 0.01). Regression analysis showed that adiponectin was independently associated with insulin sensitivity (beta = 0.25; P < 0.001), inflammatory markers (C-reactive protein, interleukin-6, and fibrinogen; beta = -0.21 to -0.07; all P < 0.05), and age (beta = -0.46; P < 0.001). Adiponectin concentration was higher in active subjects than in sedentary subjects (26.3 +/- 12.8 microg/mL vs. 17.6 +/- 6.9 microg/mL; P = 0.001), and this difference persisted after adjustment for age, sex, waist circumference, and HDL and LDL cholesterol. These results suggest that in elderly Chinese subjects, adiponectin is inversely associated with insulin resistance, systemic inflammation, and age. The lack of significant differences in levels of adiponectin between active and sedentary subjects suggests a role for adip

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